Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of <40 g/day (for adults) ie, generally in patients with a glomerular filtration rate (GFR) <25 mL/min. CKD, diabetic nephropathy patients with proteinuria, creatininie clearance less than 50ml/min. Chronic renal insufficiency in compensated or decompensated retention.